Exclusive to vertebrates, chemokines (also called intercrines, or chemotactic cytokines) are a family of highly conserved secreted proteins of 8-15 kDa size, whose main role is to control immune cell trafficking, mainly leucocytes. An important attribute of chemokines is that they can be produced by the very cells they attract to inflammatory sites.
Chemokine ligands interact with 7-transmembrane-spanning family of 19 canonical specific receptors (cCKRs) and 4 atypical chemokine receptors (ACKRs). Together, these 23 chemokines receptors form the class A G-protein-coupled receptors (GPCRs) family. The atypical receptors, expressed by non-leukocyte cell types, have the particularity of being able to trigger signals through non-G protein-coupled mechanisms.
The 46 human chemokines have been classified into four classes depending on the number and positioning of four conserved cysteine residues (Oppenheim et al., 1991; Schall, 1991), giving birth to C, CC, CXC, and CX3C families.
Exhibitor Data Sheet