BMBF funds junior research group for 3D bioprinting project

Junior Professor Dr Daniela Duarte Campos has been awarded a substantial grant from the Federal Ministry of Education and Research (BMBF). She and her junior research group are investigating bioprinting for tissue and organ engineering at the Center for Molecular Biology of Heidelberg University and at the “3D Matter Made to Order” Cluster of Excellence, a collaboration between Ruperto Carola and Karlsruhe Institute of Technology (KIT). Through the BMBF’s “NanoMatFutur” funding competition, her research project on three-dimensional “printing” of the human cornea has been awarded financial support of approximately 2.2 million euros. The long-term goal of the project is to circumvent risky transplantations and establish a conservative method of clinical treatment for irreversibly damaged corneas.

In her research, Prof. Duarte Campos is developing bio-based techniques and materials for use in so-called tissue and organ engineering. In this process, endogenous tissue is cultivated in the laboratory and then transplanted into the human body where it replaces damaged structures. An example from medical practice is tissue grown to replace destroyed joint cartilage. The substrates for these cell cultures are hydrogels – aqueous solutions in which the cells are arranged in their predetermined structures. In her BMBF-funded project entitled “BlindZero”, Prof. Duarte Campos focuses on irreversible diseases of the human cornea. Using a new process based on innovative hydrogels and a special technique of three-dimensional printing – known as 3D bioprinting –, she hopes to open up the possibility to one day “print” specially cultivated corneal tissue directly onto the eye of the affected patient.

“When injuries, infections or congenital defects result in damage to the cornea that cannot be treated using conventional methods, until now only transplantation was an option. Corneal transplantations are done quite frequently, but in spite of considerable progress, they are still fraught with complications such as rejections,” explains Daniela Duarte Campos. She hopes to circumvent these issues by propagating the patient’s own cells, adding appropriate hydrogels, and then putting them into a special 3D printer. “The idea is to apply this mixture directly to the patient’s eye in a single surgical intervention and thus generate a new cornea. This concept will first be tested with human cells in the laboratory and later further analysed using preclinical models,” explains the researcher, who is a member of the newly established Faculty of Engineering Sciences at Heidelberg University.

MEDICA-tradefair.com; Source: University of Heidelberg